Sodium Thiosulfate

5.36 Sodium Thiosulfate
 
 

ACTIONS
Sodium thiosulfate converts cyanide to the less toxic thiocyanate. The thiocyanate is then excreted in the urine.

INDICATIONS
Used in acute cyanide toxicity; not useful in hydrogen sulfide toxicity.

CONTRAINDICATIONS
None in acute cyanide toxicity.

DOSAGE
Adult: 12.5 g (50 mL of 25% solution) given by slow IV over 10 minutes.