Vasopressin

5.43 Vasopressin
 
 

CLASS
Posterior pituitary hormone

ACTIONS
Vasopressin is the naturally occurring antidiuretic hormone. In unnaturally high doses much higher than those needed for antidiuretic hormone effects vasopressin acts as a non-adrenergic peripheral vasoconstrictor. Vasopressin acts by direct stimulation of smooth muscle V1 receptors. In recent studies, after a short duration of ventricular fibrillation, vasopressin during CPR increased coronary perfusion pressure, vital organ blood flow, ventricular fibrillation median frequency, and cerebral oxygen delivery.

INDICATIONS
Vasopressin is indicated for patients with shock-refractory VF and VT without a pulse.

CONTRAINDICATIONS
None in the adult cardiac arrest. Not indicated in children under 12 years old

PRECAUTIONS
None in cardiac arrest.

ADVERSE REACTIONS AND SIDE EFFECTS
None in cardiac arrest.

DOSAGE
Adult: 40 units IV push or ET.